Custom Purified Nucleic Acids
Medchemexpress LLC Xl888 | 1149705-71-4 | MFCD22124888 | 99.4% | C29H37N5O3 | 10MG
XL888 is an orally bioavailable, ATP-competitive small-molecule inhibitor of heat shock protein 90 (HSP90) used in oncology research. It destabilizes HSP90 client proteins, leading to cell cycle arrest and apoptosis, and has demonstrated anti-proliferative and anti-tumor activity in preclinical studies. Reported biochemical potency against HSP90 is ~24 nM.
- Orally bioavailable small-molecule suitable for in vivo and in vitro studies.
- ATP-competitive mechanism that targets HSP90 chaperone activity.
- Demonstrated anti-proliferative and pro-apoptotic effects in cancer cell lines.
- Reported low nanomolar biochemical potency in cell-free assays.
- Useful for pharmacology and mechanism-of-action studies involving HSP90 clients.
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